SrasV1, France, Analysis, bibRecord, 000168

miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors.

Identifieur interne : 000168 ( France/Analysis ); précédent : 000167; suivant : 000169

miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors.

Auteurs : Marion Coolen [France] ; Denis Thieffry [France] ; Yvind Drivenes [Norvège] ; Thomas S. Becker [Norvège] ; Laure Bally-Cuif [France]

Source :

Developmental Cell [ 1534-5807 ] ; 2012-05-15.

RBID : Hal:hal-00732227

Abstract

The timing of commitment and cell-cycle exit within progenitor populations during neurogenesis is a fundamental decision that impacts both the number and identity of neurons produced during development. We show here that microRNA-9 plays a key role in this process through the direct inhibition of targets with antagonistic functions. Across the ventricular zone of the developing zebrafish hindbrain, miR-9 expression occurs at a range of commitment stages. Abrogating miR-9 function transiently delays cell-cycle exit, leading to the increased generation of late-born neuronal populations. Target protection analyses in vivo identify the progenitor-promoting genes her6 and zic5 and the cell-cycle exit-promoting gene elavl3/HuC as sequential targets of miR-9 as neurogenesis proceeds. We propose that miR-9 activity generates an ambivalent progenitor state poised to respond to both progenitor maintenance and commitment cues, which may be necessary to adjust neuronal production to local extrinsic signals during late embryogenesis.

Url:

https://hal.archives-ouvertes.fr/hal-00732227

DOI: 10.1016/j.devcel.2012.03.003

Affiliations:

France, Norvège

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000184
to stream Hal, to step Curation: 000184
to stream Hal, to step Checkpoint: 000114
to stream Main, to step Merge: 001C26
to stream Main, to step Curation: 001C16
to stream Main, to step Exploration: 001C16
to stream France, to step Extraction: 000168

Links to Exploration step

Hal:hal-00732227

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors.</title>
<author><name sortKey="Coolen, Marion" sort="Coolen, Marion" uniqKey="Coolen M" first="Marion" last="Coolen">Marion Coolen</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139693" status="VALID">          <orgName>Neurobiologie et Développement</orgName>
          <orgName type="acronym">N&eD</orgName>
          <desc>            <address>              <addrLine>Institut de Neurobiologie Alfred Fessard, Bât 33, 1 avenue de la Terrasse 91198 Gif-sur-Yvette Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inaf.cnrs-gif.fr/ned/accueil.html</ref>
          </desc>
          <listRelation>            <relation active="#struct-92966" type="direct"></relation>
            <relation name="UPR3294" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-92966" type="direct"><org type="institution" xml:id="struct-92966" status="VALID">          <orgName>Université Paris-Sud - Paris 11</orgName>
          <orgName type="acronym">UP11</orgName>
          <desc>            <address>              <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.u-psud.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UPR3294" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Thieffry, Denis" sort="Thieffry, Denis" uniqKey="Thieffry D" first="Denis" last="Thieffry">Denis Thieffry</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106195" status="VALID">          <idno type="IdRef">157042456</idno>
          <idno type="RNSR">201019092N</idno>
          <orgName>Institut de biologie de l'ENS Paris (UMR 8197/1024)</orgName>
          <orgName type="acronym">IBENS</orgName>
          <date type="start">2010-01-01</date>
          <desc>            <address>              <addrLine>46, Rue d’Ulm75005 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ibens.ens.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-34292" type="direct"></relation>
            <relation active="#struct-59704" type="indirect"></relation>
            <relation name="U1024" active="#struct-303623" type="direct"></relation>
            <relation name="UMR8197" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-34292" type="direct"><org type="regrouplaboratory" xml:id="struct-34292" status="VALID">          <orgName>Département de Biologie - ENS Paris</orgName>
          <date type="start">1987</date>
          <desc>            <address>              <addrLine>Département de BiologieENS Ulm46 rue d 'Ulm75005 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.biologie.ens.fr/depbio/</ref>
          </desc>
          <listRelation>            <relation active="#struct-59704" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-59704" type="indirect"><org type="institution" xml:id="struct-59704" status="VALID">          <orgName>École normale supérieure - Paris</orgName>
          <orgName type="acronym">ENS Paris</orgName>
          <desc>            <address>              <addrLine>45, Rue d'Ulm - 75230 Paris cedex 05</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ens.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U1024" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8197" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Drivenes,  Yvind" sort="Drivenes,  Yvind" uniqKey="Drivenes  " first=" Yvind" last="Drivenes"> Yvind Drivenes</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-51800" status="INCOMING">          <orgName>Sars International Centre for Marine Molecular Biology</orgName>
          <desc>            <address>              <addrLine>Bergen High Technology Centre, Bergen</addrLine>
              <country key="NO"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300728" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300728" type="direct"><org type="institution" xml:id="struct-300728" status="VALID">          <orgName>University of Bergen</orgName>
          <orgName type="acronym">UIB</orgName>
          <desc>            <address>              <addrLine>Postboks 7800, NO-5020 Bergen</addrLine>
              <country key="NO"></country>
            </address>
            <ref type="url">http://www.uib.no/en</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Norvège</country>
</affiliation>
</author>
<author><name sortKey="Becker, Thomas S" sort="Becker, Thomas S" uniqKey="Becker T" first="Thomas S" last="Becker">Thomas S. Becker</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-51800" status="INCOMING">          <orgName>Sars International Centre for Marine Molecular Biology</orgName>
          <desc>            <address>              <addrLine>Bergen High Technology Centre, Bergen</addrLine>
              <country key="NO"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300728" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300728" type="direct"><org type="institution" xml:id="struct-300728" status="VALID">          <orgName>University of Bergen</orgName>
          <orgName type="acronym">UIB</orgName>
          <desc>            <address>              <addrLine>Postboks 7800, NO-5020 Bergen</addrLine>
              <country key="NO"></country>
            </address>
            <ref type="url">http://www.uib.no/en</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Norvège</country>
</affiliation>
</author>
<author><name sortKey="Bally Cuif, Laure" sort="Bally Cuif, Laure" uniqKey="Bally Cuif L" first="Laure" last="Bally-Cuif">Laure Bally-Cuif</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139693" status="VALID">          <orgName>Neurobiologie et Développement</orgName>
          <orgName type="acronym">N&eD</orgName>
          <desc>            <address>              <addrLine>Institut de Neurobiologie Alfred Fessard, Bât 33, 1 avenue de la Terrasse 91198 Gif-sur-Yvette Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inaf.cnrs-gif.fr/ned/accueil.html</ref>
          </desc>
          <listRelation>            <relation active="#struct-92966" type="direct"></relation>
            <relation name="UPR3294" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-92966" type="direct"><org type="institution" xml:id="struct-92966" status="VALID">          <orgName>Université Paris-Sud - Paris 11</orgName>
          <orgName type="acronym">UP11</orgName>
          <desc>            <address>              <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.u-psud.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UPR3294" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00732227</idno>
<idno type="halId">hal-00732227</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00732227</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00732227</idno>
<idno type="doi">10.1016/j.devcel.2012.03.003</idno>
<date when="2012-05-15">2012-05-15</date>
<idno type="wicri:Area/Hal/Corpus">000184</idno>
<idno type="wicri:Area/Hal/Curation">000184</idno>
<idno type="wicri:Area/Hal/Checkpoint">000114</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000114</idno>
<idno type="wicri:doubleKey">1534-5807:2012:Coolen M:mir:controls:the</idno>
<idno type="wicri:Area/Main/Merge">001C26</idno>
<idno type="wicri:Area/Main/Curation">001C16</idno>
<idno type="wicri:Area/Main/Exploration">001C16</idno>
<idno type="wicri:Area/France/Extraction">000168</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors.</title>
<author><name sortKey="Coolen, Marion" sort="Coolen, Marion" uniqKey="Coolen M" first="Marion" last="Coolen">Marion Coolen</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139693" status="VALID">          <orgName>Neurobiologie et Développement</orgName>
          <orgName type="acronym">N&eD</orgName>
          <desc>            <address>              <addrLine>Institut de Neurobiologie Alfred Fessard, Bât 33, 1 avenue de la Terrasse 91198 Gif-sur-Yvette Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inaf.cnrs-gif.fr/ned/accueil.html</ref>
          </desc>
          <listRelation>            <relation active="#struct-92966" type="direct"></relation>
            <relation name="UPR3294" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-92966" type="direct"><org type="institution" xml:id="struct-92966" status="VALID">          <orgName>Université Paris-Sud - Paris 11</orgName>
          <orgName type="acronym">UP11</orgName>
          <desc>            <address>              <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.u-psud.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UPR3294" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Thieffry, Denis" sort="Thieffry, Denis" uniqKey="Thieffry D" first="Denis" last="Thieffry">Denis Thieffry</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106195" status="VALID">          <idno type="IdRef">157042456</idno>
          <idno type="RNSR">201019092N</idno>
          <orgName>Institut de biologie de l'ENS Paris (UMR 8197/1024)</orgName>
          <orgName type="acronym">IBENS</orgName>
          <date type="start">2010-01-01</date>
          <desc>            <address>              <addrLine>46, Rue d’Ulm75005 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ibens.ens.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-34292" type="direct"></relation>
            <relation active="#struct-59704" type="indirect"></relation>
            <relation name="U1024" active="#struct-303623" type="direct"></relation>
            <relation name="UMR8197" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-34292" type="direct"><org type="regrouplaboratory" xml:id="struct-34292" status="VALID">          <orgName>Département de Biologie - ENS Paris</orgName>
          <date type="start">1987</date>
          <desc>            <address>              <addrLine>Département de BiologieENS Ulm46 rue d 'Ulm75005 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.biologie.ens.fr/depbio/</ref>
          </desc>
          <listRelation>            <relation active="#struct-59704" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-59704" type="indirect"><org type="institution" xml:id="struct-59704" status="VALID">          <orgName>École normale supérieure - Paris</orgName>
          <orgName type="acronym">ENS Paris</orgName>
          <desc>            <address>              <addrLine>45, Rue d'Ulm - 75230 Paris cedex 05</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ens.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U1024" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8197" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Drivenes,  Yvind" sort="Drivenes,  Yvind" uniqKey="Drivenes  " first=" Yvind" last="Drivenes"> Yvind Drivenes</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-51800" status="INCOMING">          <orgName>Sars International Centre for Marine Molecular Biology</orgName>
          <desc>            <address>              <addrLine>Bergen High Technology Centre, Bergen</addrLine>
              <country key="NO"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300728" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300728" type="direct"><org type="institution" xml:id="struct-300728" status="VALID">          <orgName>University of Bergen</orgName>
          <orgName type="acronym">UIB</orgName>
          <desc>            <address>              <addrLine>Postboks 7800, NO-5020 Bergen</addrLine>
              <country key="NO"></country>
            </address>
            <ref type="url">http://www.uib.no/en</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Norvège</country>
</affiliation>
</author>
<author><name sortKey="Becker, Thomas S" sort="Becker, Thomas S" uniqKey="Becker T" first="Thomas S" last="Becker">Thomas S. Becker</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-51800" status="INCOMING">          <orgName>Sars International Centre for Marine Molecular Biology</orgName>
          <desc>            <address>              <addrLine>Bergen High Technology Centre, Bergen</addrLine>
              <country key="NO"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300728" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300728" type="direct"><org type="institution" xml:id="struct-300728" status="VALID">          <orgName>University of Bergen</orgName>
          <orgName type="acronym">UIB</orgName>
          <desc>            <address>              <addrLine>Postboks 7800, NO-5020 Bergen</addrLine>
              <country key="NO"></country>
            </address>
            <ref type="url">http://www.uib.no/en</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Norvège</country>
</affiliation>
</author>
<author><name sortKey="Bally Cuif, Laure" sort="Bally Cuif, Laure" uniqKey="Bally Cuif L" first="Laure" last="Bally-Cuif">Laure Bally-Cuif</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139693" status="VALID">          <orgName>Neurobiologie et Développement</orgName>
          <orgName type="acronym">N&eD</orgName>
          <desc>            <address>              <addrLine>Institut de Neurobiologie Alfred Fessard, Bât 33, 1 avenue de la Terrasse 91198 Gif-sur-Yvette Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inaf.cnrs-gif.fr/ned/accueil.html</ref>
          </desc>
          <listRelation>            <relation active="#struct-92966" type="direct"></relation>
            <relation name="UPR3294" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-92966" type="direct"><org type="institution" xml:id="struct-92966" status="VALID">          <orgName>Université Paris-Sud - Paris 11</orgName>
          <orgName type="acronym">UP11</orgName>
          <desc>            <address>              <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.u-psud.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UPR3294" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.devcel.2012.03.003</idno>
<series><title level="j">Developmental Cell</title>
<idno type="ISSN">1534-5807</idno>
<imprint><date type="datePub">2012-05-15</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>The timing of commitment and cell-cycle exit within progenitor populations during neurogenesis is a fundamental decision that impacts both the number and identity of neurons produced during development. We show here that microRNA-9 plays a key role in this process through the direct inhibition of targets with antagonistic functions. Across the ventricular zone of the developing zebrafish hindbrain, miR-9 expression occurs at a range of commitment stages. Abrogating miR-9 function transiently delays cell-cycle exit, leading to the increased generation of late-born neuronal populations. Target protection analyses in vivo identify the progenitor-promoting genes her6 and zic5 and the cell-cycle exit-promoting gene elavl3/HuC as sequential targets of miR-9 as neurogenesis proceeds. We propose that miR-9 activity generates an ambivalent progenitor state poised to respond to both progenitor maintenance and commitment cues, which may be necessary to adjust neuronal production to local extrinsic signals during late embryogenesis.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Norvège</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Coolen, Marion" sort="Coolen, Marion" uniqKey="Coolen M" first="Marion" last="Coolen">Marion Coolen</name>
</noRegion>
<name sortKey="Bally Cuif, Laure" sort="Bally Cuif, Laure" uniqKey="Bally Cuif L" first="Laure" last="Bally-Cuif">Laure Bally-Cuif</name>
<name sortKey="Thieffry, Denis" sort="Thieffry, Denis" uniqKey="Thieffry D" first="Denis" last="Thieffry">Denis Thieffry</name>
</country>
<country name="Norvège"><noRegion><name sortKey="Drivenes,  Yvind" sort="Drivenes,  Yvind" uniqKey="Drivenes  " first=" Yvind" last="Drivenes"> Yvind Drivenes</name>
</noRegion>
<name sortKey="Becker, Thomas S" sort="Becker, Thomas S" uniqKey="Becker T" first="Thomas S" last="Becker">Thomas S. Becker</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000168 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000168 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Hal:hal-00732227
   |texte=   miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors.
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors.

miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri